John Nash, an American mathematician whose life, marked by acute paranoid schizophrenia, fought against his disease and developed a successful academic career that earned him the Nobel Prize in Economics in 1994.
Andrea Bocelli was born with congenital glaucoma that left him partially blind. At age 12 he suffered a blow during a football game that left him completely blind. But he is one of the best singers of all time.
Michael J. Fox, the protagonist of "Back to the Future", was diagnosed with Parkinson's in 1991 when he was only 29 years old. He was told that he should withdraw from the stage, but he did not cease to be an actor.