William Shockley, who won the 1956 Nobel in physics for inventing the transistor, was excluded as a child from a long-term study of genius because of his I.Q. the score wasn't high enough.
Frida Kahlo spent much of her life in bed suffering from severe pain. Even so, she became one of the most famous artists of all time and an icon of the twentieth century.
John Nash, an American mathematician whose life, marked by acute paranoid schizophrenia, fought against his disease and developed a successful academic career that earned him the Nobel Prize in Economics in 1994.
Stephen Hawking had been paralyzed from head to toe for over thirty years. This did not prevent him from developing his activity as an exemplary researcher and professor, and intense personal life.
Vujicic was born in 1982 without arms and legs. As a child he suffered ridicule and discrimination, and tried to commit suicide but, with time, he learned to see his potential.
Andrea Bocelli was born with congenital glaucoma that left him partially blind. At age 12 he suffered a blow during a football game that left him completely blind. But he is one of the best singers of all time.
Michael J. Fox, the protagonist of "Back to the Future", was diagnosed with Parkinson's in 1991 when he was only 29 years old. He was told that he should withdraw from the stage, but he did not cease to be an actor.