The last queen of Egypt (Cleopatra VII) was a descendant of Alexander the Great's Macedonian general Ptolemy.
Cleopatra's family was descended from the Macedonian general Ptolemy, who had picked up Egypt in the shareout after Alexander died. But 250 years then passed before Cleopatra was born – 12 generations, with all their love affairs and secret assignations.
Today we know that at least one child in 10 is not attributed to their correct biological father – “Momma's baby, Poppa's maybe”, as they say. Egypt's population included people of many different ethnicities, and naturally, that included Africans since Egypt was a part of Africa. So it's not at all unlikely that long before Cleopatra was born, her Greek heritage had become mixed with other strains.
To sum up: it is quite possible that Cleopatra was pure Macedonian Greek. But it is probable that she had some Egyptian blood, although the amount is uncertain. Certainly, it was no more than half, and probably less. The best evidence is that she was three-quarters Macedonian Greek and one-quarter Egyptian.